When we bought the house, there was very little in terms of the footprint that we took issue with. The layout of the house is actually what we loved most about to because it was perfectly compartmentalized for the way we wanted to live - walls where we wanted em & no walls where we didn't... well with the exception of the wall separating the kitchen & the dining room. The only thing that proved to be a real problem for us was that there was no mudroom off the garage and no foyer off the front door.
We needed to find a proper place for our outerwear, footwear, and accessories as we would come in & out of the house.